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References: 1.Botto LD, Yang Q

The allosteric activator TEPP-46 inhibits the expression of glycolytic genes by inducing pyruvate kinase M2 (PKM2) tetramerization and blocking its nuclear translocation

it also requires consideration of clinical symptoms and other laboratory values

NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury

Some individuals stack Dihexa with compounds like Noopept, Phenylpiracetam, or modafinil to maximize cognitive gains